Edlabad Taluka Education Society, now known as Muktainagar Taluka Education Society, was established in 1954 with the aim of providing quality education to the first generation learners of this area. The society adopted the motto "Tamasoma Jyotirgamaya," which translates to "Lead me from darkness to light." and opened Primary School and Highschool at Muktainagar followed by opening Junior College with Arts, Commerce and Science faculties. Then, Muktainagar Taluka faced various challenges and was underdeveloped in many respects. In the early 1990s, higher educational opportunities were scarce in the Taluka. Recognizing this need, Muktainagar Taluka Education Society resolved to establish an undergraduate and post graduate college to serve the students in this rural area. The vision became a reality with the establishment of Edlabad Science College, Edlabad (Now MTES’s Smt. Gadavaribai Ganpatrao Khadse College, Muktainagar in 1990. The dedicated Management of MTES played a crucial role in the foundation and overall growth of the college. They worked tirelessly to provide equal educational opportunities to the students of the area. Today the fields like Electronics, Computer Sciences, and Chemical Sciences have gained prominence, the college introduced courses in Computer Science and Electronics in 1997, followed by B.Sc. IT in 2001. Presently, the college boasts a beautiful building located on Bhusawal Road, surrounded by a natural and picturesque surrounding. The college is affiliated with the Kavayitri Bahinabai Chaudhari3North Maharashtra University, Jalgaon.

In 2003, it received approval under section 2(F) of the U.G.C. Act 1956 and in the year 2006 the college was included in the list of college under section 12B of the U.G.C. Act 1956, which denotes recognition as an institution eligible to receive central assistance. The college has been twice accredited by the neck with B and B+ grade in the year 2003 and 2016 respectively. The college has been placed twice in A grade by the university in the Academic and Administrative Audit. The college is presently ISO 9001 certified. As a part of environmental consciousness the college regularly undergoes Environmental, Energy and Green Audit. The college also got permanent affiliation in 2003. The college management has made it a priority to appoint experienced and qualified teachers in accordance with the norms set by the University and State Government. The institution is dedicated to imparting knowledge to students, with a focus on their overall progress and development.